O'Dowd, Diane K

TitleVice Provost for Academic Personnel
InstitutionUniversity of California, Irvine
DepartmentAcademic Affairs
Address509 Aldrich Hall
Zot 1000
CA 92697
Phone(949) 824-0663
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    Collapse Research 
    Collapse Research Activities and Funding
    Functional studies of epilepsy mutations in Drosophila and human iPSC-derived neu
    NIH/NINDS R01NS083009Feb 15, 2014 - Jan 31, 2019
    Role: Principal Investigator
    Role of Nicotine in Regulation of naChRs in Drosophila
    NIH/NIDA R01DA014690Sep 27, 2001 - Jun 30, 2007
    Role: Principal Investigator
    NIH/NINDS K04NS001854Sep 30, 1995 - Nov 30, 2000
    Role: Principal Investigator
    Central Synaptic Transmission in Drosophila.
    NIH/NINDS R01NS027501Aug 1, 1989 - Aug 31, 2011
    Role: Principal Investigator
    Central Synaptic Transmission in Drosophila.
    NIH/NINDS R56NS027501Aug 1, 1989 - Sep 14, 2010
    Role: Principal Investigator
    NIH/NINDS R29NS027501Aug 1, 1989 - Jul 31, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xie Y, Schutte RJ, Ng NN, Ess KC, Schwartz PH, O'Dowd D. Reproducible and efficient generation of functionally active neurons from human hiPSCs for preclinical disease modeling. Stem Cell Res. 2018 Jan; 26:84-94. PMID: 29272856.
      View in: PubMed
    2. Schutte RJ, Xie Y, Ng NN, Figueroa P, Pham AT, O'Dowd D. Astrocyte-enriched feeder layers from cryopreserved cells support differentiation of spontaneously active networks of human iPSC-derived neurons. J Neurosci Methods. 2018 Jan 15; 294:91-101. PMID: 28746822.
      View in: PubMed
    3. Dennin M, Schultz ZD, Feig A, Finkelstein N, Greenhoot AF, Hildreth M, Leibovich AK, Martin JD, Moldwin MB, O'Dowd D, Posey LA, Smith TL, Miller ER. Aligning Practice to Policies: Changing the Culture to Recognize and Reward Teaching at Research Universities. CBE Life Sci Educ. 2017; 16(4). PMID: 29196430.
      View in: PubMed
    4. Guven-Ozkan T, Busto GU, Schutte SS, Cervantes-Sandoval I, O'Dowd D, Davis RL. MiR-980 Is a Memory Suppressor MicroRNA that Regulates the Autism-Susceptibility Gene A2bp1. Cell Rep. 2016 Feb 23; 14(7):1698-1709. PMID: 26876166.
      View in: PubMed
    5. Schutte SS, Schutte RJ, Barragan EV, O'Dowd D. Model systems for studying cellular mechanisms of SCN1A-related epilepsy. J Neurophysiol. 2016 Apr; 115(4):1755-66. PMID: 26843603; PMCID: PMC4819066 [Available on 04/01/17].
    6. Brick DJ, Nethercott HE, Montesano S, Banuelos MG, Stover AE, Schutte SS, O'Dowd D, Hagerman RJ, Ono M, Hessl DR, Tassone F, Schwartz PH. The Autism Spectrum Disorders Stem Cell Resource at Children's Hospital of Orange County: Implications for Disease Modeling and Drug Discovery. Stem Cells Transl Med. 2015 Nov; 4(11):1369. PMID: 26508786; PMCID: PMC4622400.
    7. Brick DJ, Nethercott HE, Montesano S, Banuelos MG, Stover AE, Schutte SS, O'Dowd D, Hagerman RJ, Ono M, Hessl DR, Tassone F, Schwartz PH. The Autism Spectrum Disorders Stem Cell Resource at Children's Hospital of Orange County: Implications for Disease Modeling and Drug Discovery. Stem Cells Transl Med. 2014 Nov; 3(11):1275-86. PMID: 25273538; PMCID: PMC4214842.
    8. Schutte RJ, Schutte SS, Algara J, Barragan EV, Gilligan J, Staber C, Savva YA, Smith MA, Reenan R, O'Dowd D. Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current. J Neurophysiol. 2014 Aug 15; 112(4):903-12. PMID: 24805083; PMCID: PMC4122742.
    9. Narayanareddy BR, Vartiainen S, Hariri N, O'Dowd D, Gross SP. A biophysical analysis of mitochondrial movement: differences between transport in neuronal cell bodies versus processes. Traffic. 2014 Jul; 15(7):762-71. PMID: 24673933; PMCID: PMC4065622.
    10. Stover AE, Brick DJ, Nethercott HE, Banuelos MG, Sun L, O'Dowd D, Schwartz PH. Process-based expansion and neural differentiation of human pluripotent stem cells for transplantation and disease modeling. J Neurosci Res. 2013 Oct; 91(10):1247-62. PMID: 23893392; PMCID: PMC4285152.
    11. Iniguez J, Schutte SS, O'Dowd D. Cav3-type a1T calcium channels mediate transient calcium currents that regulate repetitive firing in Drosophila antennal lobe PNs. J Neurophysiol. 2013 Oct; 110(7):1490-6. PMID: 23864373; PMCID: PMC4042424.
    12. Sun L, Gilligan J, Staber C, Schutte RJ, Nguyen V, O'Dowd D, Reenan R. A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure. J Neurosci. 2012 Oct 10; 32(41):14145-55. PMID: 23055484; PMCID: PMC3482260.
    13. Anderson WA, Amasino RM, Ares M, Banerjee U, Bartel B, Corces VG, Drennan CL, Elgin SC, Epstein IR, Fanning E, Guillette LJ, Handelsman J, Hatfull GF, Hoy RR, Kelley D, Leinwand LA, Losick R, Lu Y, Lynn DG, Neuhauser C, O'Dowd D, Olivera T, Pevzner P, Richards-Kortum RR, Rine J, Sah RL, Strobel SA, Walker GC, Walt DR, Warner IM, Wessler S, Willard HF, Zare RN. Competencies: a cure for pre-med curriculum. Science. 2011 Nov 11; 334(6057):760-1. PMID: 22076362.
      View in: PubMed
    14. Ren P, Zhang H, Qiu F, Liu YQ, Gu H, O'Dowd D, Zhou QY, Hu WP. Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons. PLoS One. 2011; 6(6):e20263. PMID: 21687716; PMCID: PMC3110640.
    15. Williams AE, William AE, Aguilar-Roca NM, Tsai M, Wong M, Beaupré MM, O'Dowd D. Assessment of learning gains associated with independent exam analysis in introductory biology. CBE Life Sci Educ. 2011; 10(4):346-56. PMID: 22135369; PMCID: PMC3228653.
    16. Moravec M, Williams A, Aguilar-Roca N, O'Dowd D. Learn before lecture: A strategy that improves learning outcomes in a large introductory biology class. CBE Life Sci Educ. 2010; 9(4):473-81. PMID: 21123694; PMCID: PMC2995765.
    17. Hilgenberg LG, Pham B, Ortega M, Walid S, Kemmerly T, O'Dowd D, Smith MA. Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction. J Biol Chem. 2009 Jun 19; 284(25):16956-65. PMID: 19376779; PMCID: PMC2719333.
    18. O'Dowd D, Aguilar-Roca N. Garage demos: using physical models to illustrate dynamic aspects of microscopic biological processes. CBE Life Sci Educ. 2009; 8(2):118-22. PMID: 19487500; PMCID: PMC2689147.
    19. Gu H, Jiang SA, Campusano JM, Iniguez J, Su H, Hoang AA, Lavian M, Sun X, O'Dowd D. Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain. J Neurophysiol. 2009 Jan; 101(1):42-53. PMID: 19004991; PMCID: PMC2637009.
    20. Oh HW, Campusano JM, Hilgenberg LG, Sun X, Smith MA, O'Dowd D. Ultrastructural analysis of chemical synapses and gap junctions between Drosophila brain neurons in culture. Dev Neurobiol. 2008 Feb 15; 68(3):281-94. PMID: 18044733.
      View in: PubMed
    21. Sheeba V, Sharma VK, Gu H, Chou YT, O'Dowd D, Holmes TC. Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. J Neurosci. 2008 Jan 02; 28(1):217-27. PMID: 18171939; PMCID: PMC2692917.
    22. Sheeba V, Gu H, Sharma VK, O'Dowd D, Holmes TC. Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons. J Neurophysiol. 2008 Feb; 99(2):976-88. PMID: 18077664; PMCID: PMC2692874.
    23. Campusano JM, Su H, Jiang SA, Sicaeros B, O'Dowd D. nAChR-mediated calcium responses and plasticity in Drosophila Kenyon cells. Dev Neurobiol. 2007 Sep 15; 67(11):1520-32. PMID: 17525989.
      View in: PubMed
    24. Gu H, O'Dowd D. Whole cell recordings from brain of adult Drosophila. J Vis Exp. 2007; (6):248. PMID: 18997896; PMCID: PMC2557110.
    25. Sicaeros B, O'Dowd D. Preparation of neuronal cultures from midgastrula stage Drosophila embryos. J Vis Exp. 2007; (5):226. PMID: 18979024; PMCID: PMC2557095.
    26. Sicaeros B, Campusano JM, O'Dowd D. Primary neuronal cultures from the brains of late stage Drosophila pupae. J Vis Exp. 2007; (4):200. PMID: 18979004; PMCID: PMC2556163.
    27. Hilgenberg LG, Su H, Gu H, O'Dowd D, Smith MA. Alpha3Na+/K+-ATPase is a neuronal receptor for agrin. Cell. 2006 Apr 21; 125(2):359-69. PMID: 16630822.
      View in: PubMed
    28. Gu H, O'Dowd D. Cholinergic synaptic transmission in adult Drosophila Kenyon cells in situ. J Neurosci. 2006 Jan 04; 26(1):265-72. PMID: 16399696.
      View in: PubMed
    29. Jiang SA, Campusano JM, Su H, O'Dowd D. Drosophila mushroom body Kenyon cells generate spontaneous calcium transients mediated by PLTX-sensitive calcium channels. J Neurophysiol. 2005 Jul; 94(1):491-500. PMID: 15772240.
      View in: PubMed
    30. Schwartz PH, Bryant PJ, Fuja TJ, Su H, O'Dowd D, Klassen H. Isolation and characterization of neural progenitor cells from post-mortem human cortex. J Neurosci Res. 2003 Dec 15; 74(6):838-51. PMID: 14648588.
      View in: PubMed
    31. Su H, O'Dowd D. Fast synaptic currents in Drosophila mushroom body Kenyon cells are mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors and picrotoxin-sensitive GABA receptors. J Neurosci. 2003 Oct 08; 23(27):9246-53. PMID: 14534259.
      View in: PubMed
    32. Lee D, Su H, O'Dowd D. GABA receptors containing Rdl subunits mediate fast inhibitory synaptic transmission in Drosophila neurons. J Neurosci. 2003 Jun 01; 23(11):4625-34. PMID: 12805302.
      View in: PubMed
    33. Rohrbough J, O'Dowd D, Baines RA, Broadie K. Cellular bases of behavioral plasticity: establishing and modifying synaptic circuits in the Drosophila genetic system. J Neurobiol. 2003 Jan; 54(1):254-71. PMID: 12486708.
      View in: PubMed
    34. Hodges DD, Lee D, Preston CF, Boswell K, Hall LM, O'Dowd D. tipE regulates Na+-dependent repetitive firing in Drosophila neurons. Mol Cell Neurosci. 2002 Mar; 19(3):402-16. PMID: 11906212.
      View in: PubMed
    35. Hilgenberg LG, Ho KD, Lee D, O'Dowd D, Smith MA. Agrin regulates neuronal responses to excitatory neurotransmitters in vitro and in vivo. Mol Cell Neurosci. 2002 Jan; 19(1):97-110. PMID: 11817901.
      View in: PubMed