Christopher Vanderwal

Title(s)Professor, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-6702
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    Collapse Research 
    Collapse Research Activities and Funding
    Hit-to-Lead Development of the Kalihinol Scaffold for Malaria Treatment
    NIH R01AI138139Sep 21, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Cyclization Cascades to Access Bioactive Diterpenoids
    NIH R01GM129264Aug 1, 2018 - Jul 31, 2022
    Role: Principal Investigator
    Probing and Engineering of Iterative Polyketide Synthase
    NIH R01GM127728Jun 10, 2018 - Mar 31, 2022
    Role: Co-Principal Investigator
    Structural Elucidation, Synthesis and Study of the Chlorosulfolipids
    NIH R01GM086483Jan 1, 2010 - Dec 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Evolution of a Short and Stereocontrolled Synthesis of (+)-7,20-Diisocyanoadociane. J Org Chem. 2022 01 21; 87(2):1398-1420. Roosen PC, Karns AS, Ellis BD, Vanderwal CD. PMID: 34990544; PMCID: PMC9336542.
      View in: PubMed   Mentions:    Fields:    
    2. Soft Enolization of 3-Substituted Cycloalkanones Exhibits Significantly Improved Regiocontrol vs Hard Enolization Conditions. Org Lett. 2021 12 17; 23(24):9616-9619. Dwulet NC, Ramella V, Vanderwal CD. PMID: 34870436; PMCID: PMC8766248.
      View in: PubMed   Mentions:    Fields:    
    3. Stereocontrolled Synthesis and Structural Revision of Plebeianiol A. Org Lett. 2021 12 17; 23(24):9569-9573. Johnson LK, Niman SW, Vrubliauskas D, Vanderwal CD. PMID: 34851132; PMCID: PMC8766249.
      View in: PubMed   Mentions:    Fields:    
    4. Stereocontrolled Radical Bicyclizations of Oxygenated Precursors Enable Short Syntheses of Oxidized Abietane Diterpenoids. J Am Chem Soc. 2021 02 24; 143(7):2944-2952. Vrubliauskas D, Gross BM, Vanderwal CD. PMID: 33555176; PMCID: PMC8112877.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    5. The Recurring Roles of Chlorine in Synthetic and Biological Studies of the Lissoclimides. Acc Chem Res. 2021 03 02; 54(5):1131-1142. Pak BS, Supantanapong N, Vanderwal CD. PMID: 33544578; PMCID: PMC8112881.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Synthetic strategies for mining the information-rich content of natural products for biology and medicine. Nat Prod Rep. 2020 11 18; 37(11):1393-1394. Romo D, Vanderwal CD. PMID: 33169772.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Dopaminergic Control of Striatal Cholinergic Interneurons Underlies Cocaine-Induced Psychostimulation. Cell Rep. 2020 04 21; 31(3):107527. Lewis RG, Serra M, Radl D, Gori M, Tran C, Michalak SE, Vanderwal CD, Borrelli E. PMID: 32320647.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. Cobalt-Catalyzed Hydrogen-Atom Transfer Induces Bicyclizations that Tolerate Electron-Rich and Electron-Deficient Intermediate Alkenes. Angew Chem Int Ed Engl. 2020 04 06; 59(15):6115-6121. Vrubliauskas D, Vanderwal CD. PMID: 31991035; PMCID: PMC7124983.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    9. Concise Formal Synthesis of the Pseudopterosins via Anionic Oxy-Cope/Transannular Michael Addition Cascade. Org Lett. 2020 04 17; 22(8):2883-2886. Ramella V, Roosen PC, Vanderwal CD. PMID: 32077289; PMCID: PMC7278522.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    10. Identification of Adenosine-to-Inosine RNA Editing with Acrylonitrile Reagents. Org Lett. 2019 10 04; 21(19):7948-7951. Li Y, Göhl M, Ke K, Vanderwal CD, Spitale RC. PMID: 31516001; PMCID: PMC7308179.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    11. Concise Synthesis of the Antiplasmodial Isocyanoterpene 7,20-Diisocyanoadociane. Angew Chem Int Ed Engl. 2019 09 23; 58(39):13749-13752. Karns AS, Ellis BD, Roosen PC, Chahine Z, Le Roch KG, Vanderwal CD. PMID: 31270921; PMCID: PMC6759395.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    12. A Novel Polyhalogenated Monoterpene Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Cells. Mar Drugs. 2019 Jul 25; 17(8). El Gaafary M, Hafner S, Lang SJ, Jin L, Sabry OM, Vogel CV, Vanderwal CD, Syrovets T, Simmet T. PMID: 31349625; PMCID: PMC6723102.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. A Chlorine-Atom-Controlled Terminal-Epoxide-Initiated Bicyclization Cascade Enables a Synthesis of the Potent Cytotoxins Haterumaimides J and K. J Am Chem Soc. 2019 06 12; 141(23):9202-9206. Michalak SE, Nam S, Kwon DM, Horne DA, Vanderwal CD. PMID: 31129963; PMCID: PMC6613971.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    14. Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome. Nucleic Acids Res. 2019 04 08; 47(6):3223-3232. Pellegrino S, Meyer M, Könst ZA, Holm M, Voora VK, Kashinskaya D, Zanette C, Mobley DL, Yusupova G, Vanderwal CD, Blanchard SC, Yusupov M. PMID: 30759226; PMCID: PMC6451132.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands. Int J Mol Sci. 2019 Mar 20; 20(6). Balaguer FA, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, Sorensen EJ, Vanderwal CD, Altmann KH, Mooberry SL, Steinmetz MO, Oliva MÁ, Prota AE, Díaz JF. PMID: 30897704; PMCID: PMC6471726.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    16. Correction to Catalyst-Controlled Stereoselective Synthesis Secures the Structure of the Antimalarial Isocyanoterpene Pustulosaisonitrile-1. J Org Chem. 2018 Aug 17; 83(16):9571-9572. White AM, Dao K, Vrubliauskas D, Konst ZA, Pierens GK, Mándi A, Andrews KT, Skinner-Adams TS, Clarke ME, Narbutas PT, Sim DC, Cheney KL, Kurtán T, Garson MJ, Vanderwal CD. PMID: 30062886.
      View in: PubMed   Mentions:    Fields:    
    17. An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase. J Am Chem Soc. 2018 04 18; 140(15):4961-4964. Ellis BD, Milligan JC, White AR, Duong V, Altman PX, Mohammed LY, Crump MP, Crosby J, Luo R, Vanderwal CD, Tsai SC. PMID: 29620883; PMCID: PMC6625825.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    18. Catalyst-Controlled Stereoselective Synthesis Secures the Structure of the Antimalarial Isocyanoterpene Pustulosaisonitrile-1. J Org Chem. 2017 12 15; 82(24):13313-13323. White AM, Dao K, Vrubliauskas D, Könst ZA, Pierens GK, Mándi A, Andrews KT, Skinner-Adams TS, Clarke ME, Narbutas PT, Sim DC, Cheney KL, Kurtán T, Garson MJ, Vanderwal CD. PMID: 29124922.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Hughes and Gleason's Virosaine A-Appreciating the Art in Synthesis. Angew Chem Int Ed Engl. 2017 Nov 06; 56(45):13940-13942. Ellis BD, Vanderwal CD. PMID: 29024223.
      View in: PubMed   Mentions:    Fields:    
    20. Introduction: Natural Product Synthesis. Chem Rev. 2017 09 27; 117(18):11649-11650. Herzon SB, Vanderwal CD. PMID: 28950704.
      View in: PubMed   Mentions: 3     Fields:    
    21. A Direct Synthesis of Highly Substituted π-Rich Aromatic Heterocycles from Oxetanes. Angew Chem Int Ed Engl. 2017 08 21; 56(35):10525-10529. White AR, Kozlowski RA, Tsai SC, Vanderwal CD. PMID: 28662280.
      View in: PubMed   Mentions: 8     Fields:    
    22. Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides. Nat Chem. 2017 11; 9(11):1140-1149. Könst ZA, Szklarski AR, Pellegrino S, Michalak SE, Meyer M, Zanette C, Cencic R, Nam S, Voora VK, Horne DA, Pelletier J, Mobley DL, Yusupova G, Yusupov M, Vanderwal CD. PMID: 29064494; PMCID: PMC6021127.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    23. General Approaches to Structurally Diverse Isocyanoditerpenes. J Org Chem. 2017 05 05; 82(9):4533-4541. Daub ME, Roosen PC, Vanderwal CD. PMID: 28402638.
      View in: PubMed   Mentions: 1     Fields:    
    24. Antimalarial Properties of Simplified Kalihinol Analogues. ACS Med Chem Lett. 2017 Mar 09; 8(3):355-360. Daub ME, Prudhomme J, Ben Mamoun C, Le Roch KG, Vanderwal CD. PMID: 28337330; PMCID: PMC5346982.
      View in: PubMed   Mentions: 7  
    25. Strategies for the Synthesis of the Halenaquinol and Xestoquinol Families of Natural Products. European J Org Chem. 2017 Mar 27; 2017(12):1567-1577. Schwarzwalder GM, Vanderwal CD. PMID: 29527124; PMCID: PMC5841243.
      View in: PubMed   Mentions:
    26. Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of Lon as a therapeutic target in glioma. Oncotarget. 2016 Nov 22; 7(47):77457-77467. Di K, Lomeli N, Wood SD, Vanderwal CD, Bota DA. PMID: 27764809; PMCID: PMC5340227.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. A Sequential Cycloaddition Strategy for the Synthesis of Alsmaphorazine B Traces a Path Through a Family of Alstonia Alkaloids. Tetrahedron. 2017 Jul 20; 73(29):4160-4171. Hong AY, Vanderwal CD. PMID: 28943664; PMCID: PMC5603193.
      View in: PubMed   Mentions: 1     Fields:    
    28. A Synthesis of Exiguaquinol Dessulfate. Chemistry. 2016 Dec 12; 22(50):17953-17957. Schwarzwalder GM, Scott DR, Vanderwal CD. PMID: 27673578; PMCID: PMC6028001.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    29. A Formal Enantiospecific Synthesis of 7,20-Diisocyanoadociane. Angew Chem Int Ed Engl. 2016 06 13; 55(25):7180-3. Roosen PC, Vanderwal CD. PMID: 27162155.
      View in: PubMed   Mentions: 3     Fields:    
    30. The Alga Ochromonas danica Produces Bromosulfolipids. Org Lett. 2016 Mar 04; 18(5):1124-7. White AR, Duggan BM, Tsai SC, Vanderwal CD. PMID: 26889956; PMCID: PMC6020021.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. A Failed Late-Stage Epimerization Thwarts an Approach to Ineleganolide. J Org Chem. 2016 Mar 04; 81(5):1819-38. Horn EJ, Silverston JS, Vanderwal CD. PMID: 26863401.
      View in: PubMed   Mentions: 9     Fields:    
    32. Stereoselective Halogenation in Natural Product Synthesis. Angew Chem Int Ed Engl. 2016 Mar 24; 55(14):4396-434. Chung WJ, Vanderwal CD. PMID: 26833878; PMCID: PMC6028003.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    33. Site-Selective Aliphatic C-H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide. J Am Chem Soc. 2016 Jan 20; 138(2):696-702. Quinn RK, Könst ZA, Michalak SE, Schmidt Y, Szklarski AR, Flores AR, Nam S, Horne DA, Vanderwal CD, Alexanian EJ. PMID: 26694767; PMCID: PMC5562432.
      View in: PubMed   Mentions: 53     Fields:    
    34. A synthesis of alsmaphorazine B demonstrates the chemical feasibility of a new biogenetic hypothesis. J Am Chem Soc. 2015 Jun 17; 137(23):7306-9. Hong AY, Vanderwal CD. PMID: 26034815; PMCID: PMC4477012.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    35. Computational and experimental investigations of the formal dyotropic rearrangements of Himbert arene/allene cycloadducts. J Am Chem Soc. 2015 Jun 03; 137(21):6956-64. Pham HV, Karns AS, Vanderwal CD, Houk KN. PMID: 25961134.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    36. Synthesis and potent antimalarial activity of kalihinol B. J Am Chem Soc. 2015 Apr 22; 137(15):4912-5. Daub ME, Prudhomme J, Le Roch K, Vanderwal CD. PMID: 25815413; PMCID: PMC4415034.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    37. Synthetic methodology: catalytic control of chlorination. Nat Chem. 2015 Feb; 7(2):99-100. Atwood BR, Vanderwal CD. PMID: 25615661.
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    38. Enantioselective divergent syntheses of several polyhalogenated Plocamium monoterpenes and evaluation of their selectivity for solid tumors. Angew Chem Int Ed Engl. 2014 Nov 03; 53(45):12205-9. Vogel CV, Pietraszkiewicz H, Sabry OM, Gerwick WH, Valeriote FA, Vanderwal CD. PMID: 25220828; PMCID: PMC4219742.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    39. Investigations into an anionic oxy-cope/transannular conjugate addition approach to 7,20-diisocyanoadociane. Org Lett. 2014 Sep 05; 16(17):4368-71. Roosen PC, Vanderwal CD. PMID: 25105694.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    40. A synthesis of the ABC tricyclic core of the clionastatins serves to corroborate their proposed structures. Org Lett. 2014 Mar 07; 16(5):1458-61. Tartakoff SS, Vanderwal CD. PMID: 24571064; PMCID: PMC3969099.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    41. General approach to the synthesis of the chlorosulfolipids danicalipin A, mytilipin A, and malhamensilipin A in enantioenriched form. J Org Chem. 2014 Mar 07; 79(5):2226-41. Chung WJ, Carlson JS, Vanderwal CD. PMID: 24494597; PMCID: PMC3954434.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    42. Approaches to the chemical synthesis of the chlorosulfolipids. Acc Chem Res. 2014 Feb 18; 47(2):718-28. Chung WJ, Vanderwal CD. PMID: 24400674; PMCID: PMC3949661.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    43. Synthesis of the tetracyclic core of exiguaquinol. Org Lett. 2013 Dec 06; 15(23):6014-7. Schwarzwalder GM, Steinhardt SE, Pham HV, Houk KN, Vanderwal CD. PMID: 24219829; PMCID: PMC3946388.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    44. Computation and experiment reveal that the ring-rearrangement metathesis of Himbert cycloadducts can be subject to kinetic or thermodynamic control. J Am Chem Soc. 2013 Nov 20; 135(46):17585-94. Lam JK, Pham HV, Houk KN, Vanderwal CD. PMID: 24111571; PMCID: PMC3899037.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    45. A synthesis of the chlorosulfolipid mytilipin A via a longest linear sequence of seven steps. Angew Chem Int Ed Engl. 2013 Sep 16; 52(38):10052-5. Chung WJ, Carlson JS, Bedke DK, Vanderwal CD. PMID: 23929596; PMCID: PMC3835569.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    46. Studies on the Himbert intramolecular arene/allene Diels-Alder cycloaddition. Mechanistic studies and expansion of scope to all-carbon tethers. J Am Chem Soc. 2013 May 15; 135(19):7339-48. Schmidt Y, Lam JK, Pham HV, Houk KN, Vanderwal CD. PMID: 23634642; PMCID: PMC3727913.
      View in: PubMed   Mentions: 10     Fields:    
    47. Complex polycyclic scaffolds by metathesis rearrangement of Himbert arene/allene cycloadducts. Org Lett. 2012 Nov 02; 14(21):5566-9. Lam JK, Schmidt Y, Vanderwal CD. PMID: 23067058.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    48. A synthesis of echinopine B. Angew Chem Int Ed Engl. 2012 Jul 23; 51(30):7572-6. Michels TD, Dowling MS, Vanderwal CD. PMID: 22711188.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    49. The Intramolecular Diels-Alder Reaction of Tryptamine-Derived Zincke Aldehydes Is a Stepwise Process. Chem Sci. 2012; 2012(3):1650-1655. Pham HV, Martin DB, Vanderwal CD, Houk KN. PMID: 22611483; PMCID: PMC3354770.
      View in: PubMed   Mentions: 6  
    50. Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site. Biochemistry. 2012 Jan 10; 51(1):329-41. Calvo E, Barasoain I, Matesanz R, Pera B, Camafeita E, Pineda O, Hamel E, Vanderwal CD, Andreu JM, López JA, Díaz JF. PMID: 22148836; PMCID: PMC3255483.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. Syntheses of strychnine, norfluorocurarine, dehydrodesacetylretuline, and valparicine enabled by intramolecular cycloadditions of Zincke aldehydes. J Org Chem. 2012 Jan 06; 77(1):17-46. Martin DB, Nguyen LQ, Vanderwal CD. PMID: 22168233.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    52. Reactivity and synthesis inspired by the Zincke ring-opening of pyridines. J Org Chem. 2011 Dec 02; 76(23):9555-67. Vanderwal CD. PMID: 21877712.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    53. Unraveling the mechanism of cascade reactions of zincke aldehydes. J Am Chem Soc. 2011 Mar 23; 133(11):3895-905. Paton RS, Steinhardt SE, Vanderwal CD, Houk KN. PMID: 21351736.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    54. Chlorosulfolipids: structure, synthesis, and biological relevance. Nat Prod Rep. 2011 Jan; 28(1):15-25. Bedke DK, Vanderwal CD. PMID: 21125121; PMCID: PMC3021328.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    55. Ring-closing metathesis of allylsilanes as a flexible strategy toward cyclic terpenes. short syntheses of teucladiol, isoteucladiol, poitediol, and dactylol and an attempted synthesis of caryophyllene. J Org Chem. 2010 Oct 15; 75(20):6908-22. Dowling MS, Vanderwal CD. PMID: 20836562.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    56. Concise formal synthesis of porothramycins A and B via Zincke pyridinium ring-opening/ring-closing cascade. Org Lett. 2010 Jul 02; 12(13):3093-5. Michels TD, Kier MJ, Kearney AM, Vanderwal CD. PMID: 20527899.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    57. Synthetic strategy: without a trace. Nat Chem. 2010 Apr; 2(4):254-6. Steinhardt SE, Vanderwal CD. PMID: 21124503.
      View in: PubMed   Mentions: 2     Fields:    
    58. Concise synthesis of (-)-nakadomarin A. Angew Chem Int Ed Engl. 2010 Apr 06; 49(16):2830-2. Martin DB, Vanderwal CD. PMID: 20301158.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    59. A concise enantioselective synthesis of the chlorosulfolipid malhamensilipin A. J Am Chem Soc. 2010 Mar 03; 132(8):2542-3. Bedke DK, Shibuya GM, Pereira AR, Gerwick WH, Vanderwal CD. PMID: 20141139; PMCID: PMC2830791.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    60. Structure revision and absolute configuration of malhamensilipin A from the freshwater chrysophyte Poterioochromonas malhamensis. J Nat Prod. 2010 Feb 26; 73(2):279-83. Pereira AR, Byrum T, Shibuya GM, Vanderwal CD, Gerwick WH. PMID: 20099812; PMCID: PMC2829345.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    61. Ring-closing metathesis of allylsilanes/electrophilic desilylation to prepare exo-methylidenecycloalkanes. Short syntheses of teucladiol and poitediol. J Am Chem Soc. 2009 Oct 28; 131(42):15090-1. Dowling MS, Vanderwal CD. PMID: 19788178.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    62. Complex polycyclic lactams from pericyclic cascade reactions of Zincke aldehydes. J Am Chem Soc. 2009 Jun 10; 131(22):7546-7. Steinhardt SE, Vanderwal CD. PMID: 19449870.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    63. Relative stereochemistry determination and synthesis of the major chlorosulfolipid from Ochromonas danica. J Am Chem Soc. 2009 Jun 10; 131(22):7570-2. Bedke DK, Shibuya GM, Pereira A, Gerwick WH, Haines TH, Vanderwal CD. PMID: 19445461.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    64. Efficient access to the core of the Strychnos, Aspidosperma and Iboga alkaloids. A short synthesis of norfluorocurarine. J Am Chem Soc. 2009 Mar 18; 131(10):3472-3. Martin DB, Vanderwal CD. PMID: 19236094.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    65. Synthesis and characterization of all four diastereomers of 3,4-dichloro-2-pentanol, motifs relevant to the chlorosulfolipids. J Org Chem. 2009 Mar 06; 74(5):2175-8. Kanady JS, Nguyen JD, Ziller JW, Vanderwal CD. PMID: 19161314.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    66. Organic chemistry: Chlorine lends a helping hand. Nature. 2009 Jan 29; 457(7229):548-9. Bedke DK, Vanderwal CD. PMID: 19177122.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    67. Synthesis of delta-tributylstannyl-alpha,beta,gamma,delta-unsaturated aldehydes from pyridines. Org Lett. 2008 Nov 06; 10(21):4787-90. Michels TD, Rhee JU, Vanderwal CD. PMID: 18817407.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    68. Stereoselective dichlorination of allylic alcohol derivatives to access key stereochemical arrays of the chlorosulfolipids. J Am Chem Soc. 2008 Sep 17; 130(37):12514-8. Shibuya GM, Kanady JS, Vanderwal CD. PMID: 18717563.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    69. Stereocontrolled synthesis of Z-dienes via an unexpected pericyclic cascade rearrangement of 5-amino-2,4-pentadienals. J Am Chem Soc. 2008 Jun 18; 130(24):7560-1. Steinhardt SE, Silverston JS, Vanderwal CD. PMID: 18505251.
      View in: PubMed   Mentions: 3     Fields:    
    70. Interaction of a cyclostreptin analogue with the microtubule taxoid site: the covalent reaction rapidly follows binding. J Nat Prod. 2008 Mar; 71(3):370-4. Bai R, Vanderwal CD, Díaz JF, Hamel E. PMID: 18298077.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    71. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. Nat Chem Biol. 2007 Feb; 3(2):117-25. Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G, Vanderwal CD, Day BW, Sorensen EJ, López JA, Andreu JM, Hamel E, Díaz JF. PMID: 17206139.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    72. Synthesis of nitrogen heterocycles by the ring opening of pyridinium salts. Angew Chem Int Ed Engl. 2006 Nov 27; 45(46):7803-6. Kearney AM, Vanderwal CD. PMID: 17072923.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    73. Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site. Biochemistry. 2005 Aug 30; 44(34):11525-38. Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E. PMID: 16114889.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    74. Enantioselective formal hydration of alpha,beta-unsaturated imides by Al-catalyzed conjugate addition of oxime nucleophiles. J Am Chem Soc. 2004 Nov 17; 126(45):14724-5. Vanderwal CD, Jacobsen EN. PMID: 15535689.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
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