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Highly efficient base editing at PCSK9 and normal human embryo development. Nature. 2026 Sep 09.
Jerabek S, Jung C, Kappy M, Zhao Q, Sung J, Wang N, Kim E, Kim J, Kulmann MIR, King MB, McAndrew MJ, Li M, Bhatele S, Isado M, Jang HS, Dolezal M, Prosser R, Xu S, Hwang GH, Pichova I, Xu J, Marin D, Woo JS, Bae S, Treff N, Lapinaite A, Egli D. PMID: 42742174.
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Redirecting endogenous allies. Nat Chem Biol. 2026 Jun; 22(6):858-859.
Savickyte I, Shivkumar A, Lapinaite A. PMID: 41272320.
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Preparation of high-purity RNPs of CRISPR-based DNA base editors. Methods Enzymol. 2025; 712:277-315.
McAndrew MJ, King MB, Lapinaite A. PMID: 40121077.
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1 Fields:
Translation:
Humans
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Dimerization of the deaminase domain and locking interactions with Cas9 boost base editing efficiency in ABE8e. Nucleic Acids Res. 2024 12 11; 52(22):13931-13944.
Arantes PR, Chen X, Sinha S, Saha A, Patel AC, Sample M, Nierzwicki L, Lapinaite A, Palermo G. PMID: 39569582; PMCID: PMC11662675.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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The genetic engineering Swiss army knife. Nat Chem. 2024 06; 16(6):1034.
King MB, Perry KN, McAndrew MJ, Lapinaite A. PMID: 38844636.
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Humans
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RNA-based programmable DNA cleavage. Nat Chem Biol. 2024 Jun; 20(6):664-665.
King MB, Lapinaite A. PMID: 38730193.
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1 Fields:
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Cells
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CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes. Nucleic Acids Res. 2024 01 05; 52(D1):D590-D596.
Adler BA, Trinidad MI, Bellieny-Rabelo D, Zhang E, Karp HM, Skopintsev P, Thornton BW, Weissman RF, Yoon PH, Chen L, Hessler T, Eggers AR, Colognori D, Boger R, Doherty EE, Tsuchida CA, Tran RV, Hofman L, Shi H, Wasko KM, Zhou Z, Xia C, Al-Shimary MJ, Patel JR, Thomas VCJX, Pattali R, Kan MJ, Vardapetyan A, Yang A, Lahiri A, Maxwell MF, Murdock AG, Ramit GC, Henderson HR, Calvert RW, Bamert RS, Knott GJ, Lapinaite A, Pausch P, Cofsky JC, Sontheimer EJ, Wiedenheft B, Fineran PC, Brouns SJJ, Sashital DG, Thomas BC, Brown CT, Goltsman DSA, Barrangou R, Siksnys V, Banfield JF, Savage DF, Doudna JA. PMID: 37889041; PMCID: PMC10767948.
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14 Fields:
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Unlocking the secrets of ABEs: the molecular mechanism behind their specificity. Biochem Soc Trans. 2023 08 31; 51(4):1635-1646.
Chen X, McAndrew MJ, Lapinaite A. PMID: 37526140; PMCID: PMC10586758.
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3 Fields:
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Methods special issue: RNA-targeting technologies. Methods. 2023 04; 212:10-11.
Knott GJ, Lapinaite A, O'Connell MR. PMID: 36792042.
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What are the current bottlenecks in developing and applying CRISPR technologies? Cell Syst. 2022 08 17; 13(8):589-593.
Kellogg EH, Gootenberg J, Abudayyeh O, Wong ASL, Dahlman JE, Lapinaite A, Myhrvold C, Liu CC, Hsu PD, Mali P, Qi LS. PMID: 35981511.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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CRISPR Gets Its Origin Story. CRISPR J. 2021 10; 4(5):631-633.
Knott GJ, Lapinaite A. PMID: 34661430.
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1 Fields:
Translation:
Cells
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DNA capture by a CRISPR-Cas9-guided adenine base editor. Science. 2020 07 31; 369(6503):566-571.
Lapinaite A, Knott GJ, Palumbo CM, Lin-Shiao E, Richter MF, Zhao KT, Beal PA, Liu DR, Doudna JA. PMID: 32732424; PMCID: PMC8598131.
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110 Fields:
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Cells
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Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity. Nat Biotechnol. 2020 Jul; 38(7):901.
Richter MF, Zhao KT, Eton E, Lapinaite A, Newby GA, Thuronyi BW, Wilson C, Koblan LW, Zeng J, Bauer DE, Doudna JA, Liu DR. PMID: 32433548.
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12 Fields:
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Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity. Nat Biotechnol. 2020 07; 38(7):883-891.
Richter MF, Zhao KT, Eton E, Lapinaite A, Newby GA, Thuronyi BW, Wilson C, Koblan LW, Zeng J, Bauer DE, Doudna JA, Liu DR. PMID: 32433547; PMCID: PMC7357821.
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PubMed Mentions:
583 Fields:
Translation:
HumansCells
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Small-Angle Neutron Scattering of RNA-Protein Complexes. Methods Mol Biol. 2020; 2113:165-188.
Lapinaite A, Carlomagno T, Gabel F. PMID: 32006315.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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Programmable RNA recognition using a CRISPR-associated Argonaute. Proc Natl Acad Sci U S A. 2018 Mar 27; 115(13):3368-3373.
Lapinaite A, Doudna JA, Cate JHD. PMID: 29531059; PMCID: PMC5879674.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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Archaea box C/D enzymes methylate two distinct substrate rRNA sequences with different efficiency. RNA. 2016 May; 22(5):764-72.
Graziadei A, Masiewicz P, Lapinaite A, Carlomagno T. PMID: 26925607; PMCID: PMC4836650.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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The structure of the box C/D enzyme reveals regulation of RNA methylation. Nature. 2013 Oct 24; 502(7472):519-23.
Lapinaite A, Simon B, Skjaerven L, Rakwalska-Bange M, Gabel F, Carlomagno T. PMID: 24121435.
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PubMed Mentions:
79 Fields:
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Cells
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DNA unmethylome profiling by covalent capture of CpG sites. Nat Commun. 2013; 4:2190.
Kriukiene E, Labrie V, Khare T, Urbanaviciute G, Lapinaite A, Koncevicius K, Li D, Wang T, Pai S, Ptak C, Gordevicius J, Wang SC, Petronis A, Klimašauskas S. PMID: 23877302.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012 Dec; 19(12):1257-65.
Ballaré C, Lange M, Lapinaite A, Martin GM, Morey L, Pascual G, Liefke R, Simon B, Shi Y, Gozani O, Carlomagno T, Benitah SA, Di Croce L. PMID: 23104054; PMCID: PMC3926938.
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PubMed Mentions:
145 Fields:
Translation:
Humans
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Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA. Nucleic Acids Res. 2012 Dec; 40(22):11594-602.
Lukinavicius G, Lapinaite A, Urbanaviciute G, Gerasimaite R, Klimasauskas S. PMID: 23042683; PMCID: PMC3526304.
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PubMed Mentions:
21 Fields:
Translation:
Cells