Our site may be slower due to heavy traffic from automated "bots" and AI crawlers. We're working to fix this.

Alfred Joseph Garcia

Title(s)Assistant Health Sciences Professor, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-6141
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Divergent ventilatory responses during opioid-induced respiratory depression in response to repeated fentanyl use. Am J Physiol Lung Cell Mol Physiol. 2025 Jul 01; 329(1):L161-L171. Rai KG, Nwakudu CU, Szujewski CC, Browe BM, Fisher GE, Sharp WW, Tryba AK, Garcia AJ. PMID: 40455004; PMCID: PMC12312535.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Metabolic trade-offs in Neonatal sepsis triggered by TLR4 and TLR1/2 ligands result in unique dysfunctions in neural breathing circuits. Brain Behav Immun. 2024 Jul; 119:333-350. Joana Alves M, Browe BM, Carolina Rodrigues Dias A, Torres JM, Zaza G, Bangudi S, Blackburn J, Wang W, de Araujo Fernandes-Junior S, Fadda P, Toland A, Baer LA, Stanford KI, Czeisler C, Garcia AJ, Javier Otero J. PMID: 38561095; PMCID: PMC12128324.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury. FASEB J. 2024 01; 38(1):e23379. Piao L, Fang YH, Fisher M, Hamanaka RB, Ousta A, Wu R, Mutlu GM, Garcia AJ, Archer SL, Sharp WW. PMID: 38133921; PMCID: PMC12027350.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    4. A consequence of immature breathing induces persistent changes in hippocampal synaptic plasticity and behavior: a role of prooxidant state and NMDA receptor imbalance. Front Mol Neurosci. 2023; 16:1192833. Arias-Cavieres A, Garcia AJ. PMID: 37456523; PMCID: PMC10338931.
      View in: PubMed   Mentions:
    5. A Consequence of Immature Breathing induces Persistent Changes in Hippocampal Synaptic Plasticity and Behavior: A Role of Pro-Oxidant State and NMDA Receptor Imbalance. bioRxiv. 2023 Mar 21. Arias-Cavieres A, Garcia AJ. PMID: 36993632; PMCID: PMC10055328.
      View in: PubMed   Mentions:
    6. Gasotransmitter modulation of hypoglossal motoneuron activity. Elife. 2023 01 19; 12. Browe BM, Peng YJ, Nanduri J, Prabhakar NR, Garcia AJ. PMID: 36656752; PMCID: PMC9977277.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Performance Characteristics of a Novel 3D-Printed Bubble Intermittent Mandatory Ventilator (B-IMV) for Adult Pulmonary Support. Bioengineering (Basel). 2022 Apr 02; 9(4). Poli JA, Howard C, Garcia AJ, Remboski D, Littlewood PB, Kress JP, Kasthuri N, Comai A, Soni K, Kennedy P, Ogger J, DiBlasi RM. PMID: 35447711; PMCID: PMC9027535.
      View in: PubMed   Mentions: 2  
    8. Developmental defects and impaired network excitability in a cerebral organoid model of KCNJ11 p.V59M-related neonatal diabetes. Sci Rep. 2021 11 03; 11(1):21590. Dalgin G, Tryba AK, Cohen AP, Park SY, Philipson LH, Greeley SAW, Garcia AJ. PMID: 34732776; PMCID: PMC8566525.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    9. Microglial Activation and Neurological Outcomes in a Murine Model of Cardiac Arrest. Neurocrit Care. 2022 02; 36(1):61-70. Ousta A, Piao L, Fang YH, Vera A, Nallamothu T, Garcia AJ, Sharp WW. PMID: 34268646; PMCID: PMC8813848.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    10. Intermittent Hypoxia causes targeted disruption to NMDA receptor dependent synaptic plasticity in area CA1 of the hippocampus. Exp Neurol. 2021 10; 344:113808. Arias-Cavieres A, Fonteh A, Castro-Rivera CI, Garcia AJ. PMID: 34256046; PMCID: PMC8962677.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    11. Machine learning-based data analytic approaches for evaluating post-natal mouse respiratory physiological evolution. Respir Physiol Neurobiol. 2021 01; 283:103558. Wang W, Alzate-Correa D, Alves MJ, Jones M, Garcia AJ, Zhao J, Czeisler CM, Otero JJ. PMID: 33010456; PMCID: PMC7881416.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    12. Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non-cell autonomous developmental mechanisms. Brain Pathol. 2021 01; 31(1):84-102. Alzate-Correa D, Mei-Ling Liu J, Jones M, Silva TM, Alves MJ, Burke E, Zuñiga J, Kaya B, Zaza G, Aslan MT, Blackburn J, Shimada MY, Fernandes-Junior SA, Baer LA, Stanford KI, Kempton A, Smith S, Szujewski CC, Silbaugh A, Viemari JC, Takakura AC, Garcia AJ, Moreira TS, Czeisler CM, Otero JJ. PMID: 32654284; PMCID: PMC7881415.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    13. A HIF1a-Dependent Pro-Oxidant State Disrupts Synaptic Plasticity and Impairs Spatial Memory in Response to Intermittent Hypoxia. eNeuro. 2020 May/Jun; 7(3). Arias-Cavieres A, Khuu MA, Nwakudu CU, Barnard JE, Dalgin G, Garcia AJ. PMID: 32493757; PMCID: PMC7363479.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    14. Finding inspiration in opioid-induced respiratory depression. J Physiol. 2020 01; 598(1):3. Garcia AJ, Szujewski CC. PMID: 31675443; PMCID: PMC7039442.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    15. Respiratory rhythm generation, hypoxia, and oxidative stress-Implications for development. Respir Physiol Neurobiol. 2019 12; 270:103259. Garcia AJ, Viemari JC, Khuu MA. PMID: 31369874; PMCID: PMC7020797.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    16. Intermittent Hypoxia Disrupts Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus. J Neurosci. 2019 02 13; 39(7):1320-1331. Khuu MA, Pagan CM, Nallamothu T, Hevner RF, Hodge RD, Ramirez JM, Garcia AJ. PMID: 30587544; PMCID: PMC6381238.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    17. Chronic Intermittent Hypoxia Differentially Impacts Different States of Inspiratory Activity at the Level of the preBötzinger Complex. Front Physiol. 2017; 8:571. Garcia AJ, Dashevskiy T, Khuu MA, Ramirez JM. PMID: 28936176; PMCID: PMC5603985.
      View in: PubMed   Mentions: 28  
    18. Different roles for inhibition in the rhythm-generating respiratory network. J Neurophysiol. 2017 10 01; 118(4):2070-2088. Harris KD, Dashevskiy T, Mendoza J, Garcia AJ, Ramirez JM, Shea-Brown E. PMID: 28615332; PMCID: PMC5626906.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    19. A novel excitatory network for the control of breathing. Nature. 2016 08 04; 536(7614):76-80. Anderson TM, Garcia AJ, Baertsch NA, Pollak J, Bloom JC, Wei AD, Rai KG, Ramirez JM. PMID: 27462817; PMCID: PMC5479418.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    20. Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex. Front Neurosci. 2016; 10:4. Garcia AJ, Zanella S, Dashevskiy T, Khan SA, Khuu MA, Prabhakar NR, Ramirez JM. PMID: 26869872; PMCID: PMC4740384.
      View in: PubMed   Mentions: 41  
    21. Prostaglandin E2 differentially modulates the central control of eupnoea, sighs and gasping in mice. J Physiol. 2015 01 01; 593(1):305-19. Koch H, Caughie C, Elsen FP, Doi A, Garcia AJ, Zanella S, Ramirez JM. PMID: 25556802; PMCID: PMC4293069.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    22. The ins and outs of breathing. Elife. 2014 Jun 17; 3:e03375. Ramirez JM, Anderson TM, Garcia AJ. PMID: 24940002; PMCID: PMC4060004.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. When norepinephrine becomes a driver of breathing irregularities: how intermittent hypoxia fundamentally alters the modulatory response of the respiratory network. J Neurosci. 2014 Jan 01; 34(1):36-50. Zanella S, Doi A, Garcia AJ, Elsen F, Kirsch S, Wei AD, Ramirez JM. PMID: 24381266; PMCID: PMC3866492.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    24. β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Front Neural Circuits. 2013; 7:179. Viemari JC, Garcia AJ, Doi A, Elsen G, Ramirez JM. PMID: 24273495; PMCID: PMC3824105.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    25. Central and peripheral factors contributing to obstructive sleep apneas. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):344-53. Ramirez JM, Garcia AJ, Anderson TM, Koschnitzky JE, Peng YJ, Kumar GK, Prabhakar NR. PMID: 23770311; PMCID: PMC3901437.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    26. The physiological determinants of sudden infant death syndrome. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):288-300. Garcia AJ, Koschnitzky JE, Ramirez JM. PMID: 23735486; PMCID: PMC3812300.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    27. Post-hypoxic recovery of respiratory rhythm generation is gender dependent. PLoS One. 2013; 8(4):e60695. Garcia AJ, Rotem-Kohavi N, Doi A, Ramirez JM. PMID: 23593283; PMCID: PMC3620234.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    28. Cardiorespiratory coupling in health and disease. Auton Neurosci. 2013 Apr; 175(1-2):26-37. Garcia AJ, Koschnitzky JE, Dashevskiy T, Ramirez JM. PMID: 23497744; PMCID: PMC3683976.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    29. Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J Neurosci. 2013 Feb 27; 33(9):4165-80. Hodge RD, Garcia AJ, Elsen GE, Nelson BR, Mussar KE, Reiner SL, Ramirez JM, Hevner RF. PMID: 23447624; PMCID: PMC3623668.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    30. Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels. J Neurosci. 2013 Feb 20; 33(8):3633-45. Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJ, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM. PMID: 23426690; PMCID: PMC3652398.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    31. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci. 2012 Mar 25; 15(5):793-802. Madisen L, Mao T, Koch H, Zhuo JM, Berenyi A, Fujisawa S, Hsu YW, Garcia AJ, Gu X, Zanella S, Kidney J, Gu H, Mao Y, Hooks BM, Boyden ES, Buzsáki G, Ramirez JM, Jones AR, Svoboda K, Han X, Turner EE, Zeng H. PMID: 22446880; PMCID: PMC3337962.
      View in: PubMed   Mentions: 792     Fields:    Translation:AnimalsCells
    32. Network reconfiguration and neuronal plasticity in rhythm-generating networks. Integr Comp Biol. 2011 Dec; 51(6):856-68. Koch H, Garcia AJ, Ramirez JM. PMID: 21856733; PMCID: PMC3223481.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    33. Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus. J Neurophysiol. 2011 Dec; 106(6):3045-55. Garcia AJ, Khan SA, Kumar GK, Prabhakar NR, Ramirez JM. PMID: 21849609; PMCID: PMC3234088.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    34. Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro. Eur J Neurosci. 2011 Jun; 33(12):2228-37. Viemari JC, Garcia AJ, Doi A, Ramirez JM. PMID: 21615559; PMCID: PMC3652413.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    35. The role of spiking and bursting pacemakers in the neuronal control of breathing. J Biol Phys. 2011 Jun; 37(3):241-61. Ramirez JM, Koch H, Garcia AJ, Doi A, Zanella S. PMID: 22654176; PMCID: PMC3101325.
      View in: PubMed   Mentions: 36     Fields:    
    36. Chapter 3--networks within networks: the neuronal control of breathing. Prog Brain Res. 2011; 188:31-50. Garcia AJ, Zanella S, Koch H, Doi A, Ramirez JM. PMID: 21333801; PMCID: PMC3652403.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    37. Graded reductions in oxygenation evoke graded reconfiguration of the isolated respiratory network. J Neurophysiol. 2011 Feb; 105(2):625-39. Hill AA, Garcia AJ, Zanella S, Upadhyaya R, Ramirez JM. PMID: 21084689; PMCID: PMC3059168.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    38. Hyperoxic stimulation of synchronous orthodromic activity and induction of neural plasticity does not require changes in excitatory synaptic transmission. J Appl Physiol (1985). 2010 Sep; 109(3):820-9. Garcia AJ, Putnam RW, Dean JB. PMID: 20558752; PMCID: PMC2944636.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    39. Hyperbaric hyperoxia and normobaric reoxygenation increase excitability and activate oxygen-induced potentiation in CA1 hippocampal neurons. J Appl Physiol (1985). 2010 Sep; 109(3):804-19. Garcia AJ, Putnam RW, Dean JB. PMID: 20558753; PMCID: PMC2944633.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    40. Point: Medullary pacemaker neurons are essential for both eupnea and gasping in mammals. J Appl Physiol (1985). 2007 Aug; 103(2):717-8; discussion 722. Ramirez JM, Garcia A. PMID: 17272416.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    41. Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures. J Appl Physiol (1985). 2003 Sep; 95(3):883-909. Dean JB, Mulkey DK, Garcia AJ, Putnam RW, Henderson RA. PMID: 12909594.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    Alfred's Networks
    Concepts (216)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (1)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCI Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).
    This site is running Profiles RNS version UCSF-v3.1.0-18-gb39b692b on PROFILES-PWEB04. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California