Alexander C Minella

Title(s)Associate Clinical Professor, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
ORCID ORCID Icon0000-0001-6693-3362 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Yale University B.S.molecular biophysics and biochemistry
    Vanderbilt University School of MedicineM.D.medicine
    University of Washington School of Medicineresidency (internal medicine)
    University of Washington School of Medicine6/2004clinical fellowship (oncology)
    Fred Hutchinson Cancer Center8/2007postdoctoral fellowship (cancer biology)
    Collapse Awards and Honors
    2012American Cancer Society (ACS) Research Scholar
    2009Sidney Kimmel Foundation for Cancer Research Scholar
    2008American Society of Hematology Junior Faculty Scholar
    2008Leukemia Research Foundation New Investigator Award

    Collapse Overview 
    Collapse Overview
    Medical Director, UCI GMP facility (cell and gene therapy manufacturing)
    Associate Professor of Clinical Medicine (hematology/oncology)

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CRISPR-derived genome editing therapies: Progress from bench to bedside. Mol Ther. 2021 Nov 03; 29(11):3125-3139. Rees HA, Minella AC, Burnett CA, Komor AC, Gaudelli NM. PMID: 34619370; PMCID: PMC8572140.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    2. Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation. Neoplasia. 2020 Nov; 22(11):644-658. Meyer AE, Furumo Q, Stelloh C, Minella AC, Rao S. PMID: 33070870; PMCID: PMC7573506.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    3. Anti-B-Cell Maturation Antigen BiTE Molecule AMG 420 Induces Responses in Multiple Myeloma. J Clin Oncol. 2020 Mar 10; 38(8):775-783. Topp MS, Duell J, Zugmaier G, Attal M, Moreau P, Langer C, Krönke J, Facon T, Salnikov AV, Lesley R, Beutner K, Kalabus J, Rasmussen E, Riemann K, Minella AC, Munzert G, Einsele H. PMID: 31895611.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCellsCTClinical Trials
    4. Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1). Nucleic Acids Res. 2019 Jan 25; 47(2):970-980. Gupta AK, Murthy T, Paul KV, Ramirez O, Fisher JB, Rao S, Rosenberg AB, Seelig G, Minella AC, Pillai MM. PMID: 30462273; PMCID: PMC6344872.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. The Development and Use of Scalable Systems for Studying Aberrant Splicing in SF3B1-Mutant CLL. Methods Mol Biol. 2019; 1881:83-99. Murthy T, Paul KV, Minella AC, Pillai MM. PMID: 30350199.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Cyclin-dependent kinase 1 (CDK1) and CDK2 have opposing roles in regulating interactions of splicing factor 3B1 with chromatin. J Biol Chem. 2018 Jun 29; 293(26):10220-10234. Murthy T, Bluemn T, Gupta AK, Reimer M, Rao S, Pillai MM, Minella AC. PMID: 29764937; PMCID: PMC6028971.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    7. E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol. 2017 01 01; 37(1). Swartz KL, Wood SN, Murthy T, Ramirez O, Qin G, Pillai MM, Rao S, Minella AC. PMID: 27795297; PMCID: PMC5192079.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    8. Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures. Oncogene. 2017 Feb 23; 36(8):1123-1133. Kesarwani AK, Ramirez O, Gupta AK, Yang X, Murthy T, Minella AC, Pillai MM. PMID: 27524419; PMCID: PMC5311031.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    9. The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. J Biol Chem. 2016 Jul 15; 291(29):14939-53. Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ. PMID: 27226619; PMCID: PMC4946913.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    10. Outside the coding genome, mammalian microRNAs confer structural and functional complexity. Sci Signal. 2015 Mar 17; 8(368):re2. Olive V, Minella AC, He L. PMID: 25783159; PMCID: PMC4425368.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    11. Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation. Mol Cell Biol. 2014 Sep; 34(17):3244-58. Siu KT, Xu Y, Swartz KL, Bhattacharyya M, Gurbuxani S, Hua Y, Minella AC. PMID: 24958101; PMCID: PMC4135554.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    12. Developing a systems-based understanding of hematopoietic stem cell cycle control. Adv Exp Med Biol. 2014; 844:189-200. Siu KT, Minella AC. PMID: 25480642.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Cellular stress pathways in pediatric bone marrow failure syndromes: many roads lead to neutropenia. Pediatr Res. 2014 Jan; 75(1-2):189-95. Glaubach T, Minella AC, Corey SJ. PMID: 24192702.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition. Leukemia. 2014 May; 28(5):1041-51. Mehta HM, Futami M, Glaubach T, Lee DW, Andolina JR, Yang Q, Whichard Z, Quinn M, Lu HF, Kao WM, Przychodzen B, Sarkar CA, Minella A, Maciejewski JP, Corey SJ. PMID: 24170028; PMCID: PMC5875430.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife. 2013 Oct 15; 2:e00822. Olive V, Sabio E, Bennett MJ, De Jong CS, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig MA, Goga A, Speed TP, Xuan Z, Evan GI, Wan Y, Minella AC, He L. PMID: 24137534; PMCID: PMC3796314.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    16. Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism. Oncogene. 2014 Jun 12; 33(24):3161-71. Xu Y, Swartz KL, Siu KT, Bhattacharyya M, Minella AC. PMID: 23873023; PMCID: PMC3939062.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    17. Complex hypereosinophilia arising from post-polycythemia vera myelofibrosis: A case of imatinib-responsiveness. Leuk Res Rep. 2012; 1(1):9-12. Gentzler RD, Minella AC, Stein BL. PMID: 24371761; PMCID: PMC3787743.
      View in: PubMed   Mentions:
    18. An integrated view of cyclin E function and regulation. Cell Cycle. 2012 Jan 01; 11(1):57-64. Siu KT, Rosner MR, Minella AC. PMID: 22186781; PMCID: PMC3272232.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    19. Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Mol Cell Biol. 2011 Sep; 31(18):3885-95. Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC. PMID: 21746877; PMCID: PMC3165725.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    20. MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7. J Biol Chem. 2010 Nov 05; 285(45):34439-46. Xu Y, Sengupta T, Kukreja L, Minella AC. PMID: 20826802; PMCID: PMC2966058.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    21. Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression. J Biol Chem. 2010 Apr 09; 285(15):11258-69. Schaefer JS, Sabherwal Y, Shi HY, Sriraman V, Richards J, Minella A, Turner DP, Watson DK, Zhang M. PMID: 20139077; PMCID: PMC2857004.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    22. Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev. 2008 Jun 15; 22(12):1677-89. Minella AC, Loeb KR, Knecht A, Welcker M, Varnum-Finney BJ, Bernstein ID, Roberts JM, Clurman BE. PMID: 18559482; PMCID: PMC2428064.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    23. p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability. Oncogene. 2007 Oct 18; 26(48):6948-53. Minella AC, Grim JE, Welcker M, Clurman BE. PMID: 17486057.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    24. Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle. 2005 Oct; 4(10):1356-9. Minella AC, Clurman BE. PMID: 16131838.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    25. Ras activity regulates cyclin E degradation by the Fbw7 pathway. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9649-54. Minella AC, Welcker M, Clurman BE. PMID: 15980150; PMCID: PMC1172263.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    26. p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation. Curr Biol. 2002 Oct 29; 12(21):1817-27. Minella AC, Swanger J, Bryant E, Welcker M, Hwang H, Clurman BE. PMID: 12419181.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    27. Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells. J Virol. 2000 Mar; 74(6):2655-62. Ross TM, Narayan M, Fang ZY, Minella AC, Green PL. PMID: 10684280; PMCID: PMC111754.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    28. Molecular Pathogenesis of HTLV: A Current Perspective. Semmes OJ and Hammarskjold ML (eds). The role of the tax gene in human T-cell leukemia virus type 2-mediated transformation of human T-lymphocytes. 1998; 71-77. Green PL, Ross TM, Anderson M, and Minella AC.
    29. Mutational analysis of human T-cell leukemia virus type 2 Tax. J Virol. 1997 Nov; 71(11):8912-7. Ross TM, Minella AC, Fang ZY, Pettiford SM, Green PL. PMID: 9343258; PMCID: PMC192364.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
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