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Alexander C Minella

Photo of Alexander C Minella
Title(s)Associate Clinical Professor, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
ORCID ORCID Icon0000-0001-6693-3362 Additional info
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    Collapse Biography 
    Collapse education and training
    Yale University B.S.molecular biophysics and biochemistry
    Vanderbilt University School of MedicineM.D.medicine
    University of Washington School of Medicineresidency (internal medicine)
    University of Washington School of Medicine6/2004clinical fellowship (oncology)
    Fred Hutchinson Cancer Center8/2007postdoctoral fellowship (cancer biology)
    Collapse awards and honors
    2012  - 2017American Cancer Society (ACS) Research Scholar
    2009  - 2012Sidney Kimmel Foundation for Cancer Research Translational Scholar
    2009  - 2011American Society of Hematology Junior Faculty Scholar
    2008  - 2009Leukemia Research Foundation New Investigator Award

    Collapse Overview 
    Collapse overview
    Medical Director, UCI GMP facility (cell and gene therapy manufacturing)
    Associate Professor of Clinical Medicine (hematology/oncology)

    Collapse Research 
    Collapse research activities and funding
    Mechanisms of HIF-1 activation by cyclin E and their role in breast tumorigenesis
    American Cancer Society 22511-RSG-12-132-01-CCGJul 1, 2012 - Jun 13, 2017
    Role: Principal Investigator
    Cyclin E Regulation in Normal and Neoplastic Hematopoiesis
    NIH R01HL098608Aug 1, 2010 - Jul 31, 2016
    Role: Principal Investigator
    Deregulated cell cycle controls in the pathogenesis of hematopoietic cancers
    Sidney Kimmel Foundation Translational Scholar AwardJul 1, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Deregulated cyclin E in the pathogenesis of myelodysplasia and leukemia
    American Society of Hematology Junior Faculty Scholars AwardJul 1, 2009 - Jul 30, 2010
    Role: Principal Investigator
    The role of cyclin E deregulation in breast tumorigenesis
    NIH K22CA130984Sep 1, 2008 - Dec 31, 2011
    Role: Principal Investigator
    Mechanisms of cyclin E associated tumorigenesis
    NIH K08CA101800Jul 1, 2003 - Jun 30, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Base Editing of HBG1 and HBG2 Promoters for Sickle Cell Disease. N Engl J Med. 2026 Apr 01. Gupta AO, Sharma A, Frangoul H, Kanter J, Mapara MY, Dalal J, Alavi A, Jaroscak JJ, Ayala E, DiPersio JF, Ziga ED, Eapen M, Rifkin-Zenenberg S, Minella AC, Chen Y, Chesler S, Ambati S, Bowman TS, Habtemariam B, Joseney-Antoine M, Chockalingam PS, Lin L, Goyal S, Simon A, Thompson AA, Heeney MM, BEACON Investigators. PMID: 41931046.
      View in: PubMed   Mentions:
    2. BCMA-targeting BiTE molecule AMG 420 in relapsed or refractory multiple myeloma: a phase 1b open-label expansion study. Leuk Lymphoma. 2025 Nov; 66(11):2108-2117. Rodriguez C, Rodriguez T, Kentos A, Driessen C, Sunami K, Lesokhin AM, Yee AJ, Minella AC, Maraboina R, Upreti VV, Zhou D, Shabooti M, Stieglmaier J, Quach H. PMID: 40690374.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    3. CRISPR-derived genome editing therapies: Progress from bench to bedside. Mol Ther. 2021 Nov 03; 29(11):3125-3139. Rees HA, Minella AC, Burnett CA, Komor AC, Gaudelli NM. PMID: 34619370; PMCID: PMC8572140.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    4. Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation. Neoplasia. 2020 11; 22(11):644-658. Meyer AE, Furumo Q, Stelloh C, Minella AC, Rao S. PMID: 33070870; PMCID: PMC7573506.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    5. Anti-B-Cell Maturation Antigen BiTE Molecule AMG 420 Induces Responses in Multiple Myeloma. J Clin Oncol. 2020 03 10; 38(8):775-783. Topp MS, Duell J, Zugmaier G, Attal M, Moreau P, Langer C, Krönke J, Facon T, Salnikov AV, Lesley R, Beutner K, Kalabus J, Rasmussen E, Riemann K, Minella AC, Munzert G, Einsele H. PMID: 31895611.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansCellsCTClinical Trials
    6. Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1). Nucleic Acids Res. 2019 01 25; 47(2):970-980. Gupta AK, Murthy T, Paul KV, Ramirez O, Fisher JB, Rao S, Rosenberg AB, Seelig G, Minella AC, Pillai MM. PMID: 30462273; PMCID: PMC6344872.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. The Development and Use of Scalable Systems for Studying Aberrant Splicing in SF3B1-Mutant CLL. Methods Mol Biol. 2019; 1881:83-99. Murthy T, Paul KV, Minella AC, Pillai MM. PMID: 30350199.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Cyclin-dependent kinase 1 (CDK1) and CDK2 have opposing roles in regulating interactions of splicing factor 3B1 with chromatin. J Biol Chem. 2018 06 29; 293(26):10220-10234. Murthy T, Bluemn T, Gupta AK, Reimer M, Rao S, Pillai MM, Minella AC. PMID: 29764937; PMCID: PMC6028971.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    9. E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol. 2017 01 01; 37(1). Swartz KL, Wood SN, Murthy T, Ramirez O, Qin G, Pillai MM, Rao S, Minella AC. PMID: 27795297; PMCID: PMC5192079.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    10. Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures. Oncogene. 2017 02 23; 36(8):1123-1133. Kesarwani AK, Ramirez O, Gupta AK, Yang X, Murthy T, Minella AC, Pillai MM. PMID: 27524419; PMCID: PMC5311031.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    11. The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. J Biol Chem. 2016 07 15; 291(29):14939-53. Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ. PMID: 27226619; PMCID: PMC4946913.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    12. Outside the coding genome, mammalian microRNAs confer structural and functional complexity. Sci Signal. 2015 Mar 17; 8(368):re2. Olive V, Minella AC, He L. PMID: 25783159; PMCID: PMC4425368.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    13. Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation. Mol Cell Biol. 2014 Sep; 34(17):3244-58. Siu KT, Xu Y, Swartz KL, Bhattacharyya M, Gurbuxani S, Hua Y, Minella AC. PMID: 24958101; PMCID: PMC4135554.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    14. Developing a systems-based understanding of hematopoietic stem cell cycle control. Adv Exp Med Biol. 2014; 844:189-200. Siu KT, Minella AC. PMID: 25480642.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. Cellular stress pathways in pediatric bone marrow failure syndromes: many roads lead to neutropenia. Pediatr Res. 2014 Jan; 75(1-2):189-95. Glaubach T, Minella AC, Corey SJ. PMID: 24192702.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition. Leukemia. 2014 May; 28(5):1041-51. Mehta HM, Futami M, Glaubach T, Lee DW, Andolina JR, Yang Q, Whichard Z, Quinn M, Lu HF, Kao WM, Przychodzen B, Sarkar CA, Minella A, Maciejewski JP, Corey SJ. PMID: 24170028; PMCID: PMC5875430.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    17. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife. 2013 Oct 15; 2:e00822. Olive V, Sabio E, Bennett MJ, De Jong CS, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig MA, Goga A, Speed TP, Xuan Z, Evan GI, Wan Y, Minella AC, He L. PMID: 24137534; PMCID: PMC3796314.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    18. Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism. Oncogene. 2014 Jun 12; 33(24):3161-71. Xu Y, Swartz KL, Siu KT, Bhattacharyya M, Minella AC. PMID: 23873023; PMCID: PMC3939062.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    19. Complex hypereosinophilia arising from post-polycythemia vera myelofibrosis: A case of imatinib-responsiveness. Leuk Res Rep. 2012; 1(1):9-12. Gentzler RD, Minella AC, Stein BL. PMID: 24371761; PMCID: PMC3787743.
      View in: PubMed   Mentions:
    20. An integrated view of cyclin E function and regulation. Cell Cycle. 2012 Jan 01; 11(1):57-64. Siu KT, Rosner MR, Minella AC. PMID: 22186781; PMCID: PMC3272232.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    21. Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Mol Cell Biol. 2011 Sep; 31(18):3885-95. Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC. PMID: 21746877; PMCID: PMC3165725.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    22. MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7. J Biol Chem. 2010 Nov 05; 285(45):34439-46. Xu Y, Sengupta T, Kukreja L, Minella AC. PMID: 20826802; PMCID: PMC2966058.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    23. Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression. J Biol Chem. 2010 Apr 09; 285(15):11258-69. Schaefer JS, Sabherwal Y, Shi HY, Sriraman V, Richards J, Minella A, Turner DP, Watson DK, Zhang M. PMID: 20139077; PMCID: PMC2857004.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    24. Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev. 2008 Jun 15; 22(12):1677-89. Minella AC, Loeb KR, Knecht A, Welcker M, Varnum-Finney BJ, Bernstein ID, Roberts JM, Clurman BE. PMID: 18559482; PMCID: PMC2428064.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    25. p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability. Oncogene. 2007 Oct 18; 26(48):6948-53. Minella AC, Grim JE, Welcker M, Clurman BE. PMID: 17486057.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    26. Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle. 2005 Oct; 4(10):1356-9. Minella AC, Clurman BE. PMID: 16131838.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    27. Ras activity regulates cyclin E degradation by the Fbw7 pathway. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9649-54. Minella AC, Welcker M, Clurman BE. PMID: 15980150; PMCID: PMC1172263.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    28. p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation. Curr Biol. 2002 Oct 29; 12(21):1817-27. Minella AC, Swanger J, Bryant E, Welcker M, Hwang H, Clurman BE. PMID: 12419181.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    29. Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells. J Virol. 2000 Mar; 74(6):2655-62. Ross TM, Narayan M, Fang ZY, Minella AC, Green PL. PMID: 10684280; PMCID: PMC111754.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    30. Molecular Pathogenesis of HTLV: A Current Perspective. Semmes OJ and Hammarskjold ML (eds). The role of the tax gene in human T-cell leukemia virus type 2-mediated transformation of human T-lymphocytes. 1998; 71-77. Green PL, Ross TM, Anderson M, and Minella AC.
    31. Mutational analysis of human T-cell leukemia virus type 2 Tax. J Virol. 1997 Nov; 71(11):8912-7. Ross TM, Minella AC, Fang ZY, Pettiford SM, Green PL. PMID: 9343258; PMCID: PMC192364.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    32. Ballistocardiography in office practice. Ohio State Med J. 1954 Dec; 50(12):1145-9. MINELLA AC. PMID: 13214700.
      View in: PubMed   Mentions:    Fields:    
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