Boiko, Alexander Davidovic

Title(s)Assistant Professor, Molecular Biology & Biochemistry
Phone(949) 824-9953
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    Collapse Research 
    Collapse Research Activities and Funding
    Isolation and Characterization of Tumor Stem Cells from Melanoma Patients
    NIH/NCI R00CA154960Apr 1, 2013 - Mar 31, 2016
    Role: Principal Investigator
    Isolation and Characterization of Tumor Stem Cells from Melanoma Patients
    NIH/NCI K99CA154960Aug 9, 2011 - Jul 31, 2013
    Role: Principal Investigator
    Isolation and Characterization of Melanoma Tumor Stem Cells
    NIH/NCI F32CA126252Dec 1, 2007 - Nov 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li C, Nguyen V, Clark KN, Zahed T, Sharkas S, Filipp FV, Boiko AD. Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling. Proc Natl Acad Sci U S A. 2019 Feb 21. PMID: 30792348.
      View in: PubMed
    2. Ngo M, Han A, Lakatos A, Sahoo D, Hachey SJ, Weiskopf K, Beck AH, Weissman IL, Boiko AD. Antibody Therapy Targeting CD47 and CD271 Effectively Suppresses Melanoma Metastasis in Patient-Derived Xenografts. Cell Rep. 2016 08 09; 16(6):1701-1716. PMID: 27477289.
      View in: PubMed
    3. Hachey SJ, Boiko AD. Therapeutic implications of melanoma heterogeneity. Exp Dermatol. 2016 07; 25(7):497-500. PMID: 27060971.
      View in: PubMed
    4. Dimov IK, Boiko AD. Profiling Melanoma Heterogeneity Using Microwell RNA Cytometry. Methods Mol Biol. 2016 Apr 16. PMID: 27083169.
      View in: PubMed
    5. Boiko AD. Isolation of melanoma tumor-initiating cells from surgical tissues. Methods Mol Biol. 2013; 961:253-9. PMID: 23325649; PMCID: PMC4009373.
    6. Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1931-6. PMID: 21233420; PMCID: PMC3033256.
    7. Boiko AD, Razorenova OV, van de Rijn M, Swetter SM, Johnson DL, Ly DP, Butler PD, Yang GP, Joshua B, Kaplan MJ, Longaker MT, Weissman IL. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature. 2010 Jul 01; 466(7302):133-7. PMID: 20596026; PMCID: PMC2898751.
    8. Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR, Gudkov AV. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev. 2006 Jan 15; 20(2):236-52. PMID: 16418486; PMCID: PMC1356114.
    9. Lu T, Burdelya LG, Swiatkowski SM, Boiko AD, Howe PH, Stark GR, Gudkov AV. Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7112-7. PMID: 15118089; PMCID: PMC406474.
    10. Zou X, Ray D, Aziyu A, Christov K, Boiko AD, Gudkov AV, Kiyokawa H. Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes Dev. 2002 Nov 15; 16(22):2923-34. PMID: 12435633; PMCID: PMC187486.