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Alexander Davidovic Boiko

Title(s)Assistant Professor, Molecular Biology & Biochemistry
Address3022 Gross Hall
Zot 3900
Irvine CA 92697
Phone(949) 824-9953
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    Therapeutic Mechanism of CD47 Blockade in Suppressing Melanoma Metastasis
    NIH/NCI R01CA234892Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Isolation and Characterization of Tumor Stem Cells from Melanoma Patients
    NIH/NCI R00CA154960Apr 1, 2013 - Mar 31, 2016
    Role: Principal Investigator
    Isolation and Characterization of Tumor Stem Cells from Melanoma Patients
    NIH/NCI K99CA154960Aug 9, 2011 - Mar 31, 2013
    Role: Principal Investigator
    Isolation and Characterization of Melanoma Tumor Stem Cells
    NIH/NCI F32CA126252Dec 1, 2007 - Nov 30, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Calreticulin is a Critical Cell Survival Factor in Malignant Neoplasms. PLoS Biol. 2019 09; 17(9):e3000402. Han A, Li C, Zahed T, Wong M, Smith I, Hoedel K, Green D, Boiko AD. PMID: 31568485.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. CD271 is a molecular switch with divergent roles in melanoma and melanocyte development. Sci Rep. 2019 05 22; 9(1):7696. Filipp FV, Li C, Boiko AD. PMID: 31118427.
      View in: PubMed   Mentions:    Fields:    
    3. Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling. Proc Natl Acad Sci U S A. 2019 03 05; 116(10):4548-4557. Li C, Nguyen V, Clark KN, Zahed T, Sharkas S, Filipp FV, Boiko AD. PMID: 30792348.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Antibody Therapy Targeting CD47 and CD271 Effectively Suppresses Melanoma Metastasis in Patient-Derived Xenografts. Cell Rep. 2016 08 09; 16(6):1701-1716. Ngo M, Han A, Lakatos A, Sahoo D, Hachey SJ, Weiskopf K, Beck AH, Weissman IL, Boiko AD. PMID: 27477289.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    5. Therapeutic implications of melanoma heterogeneity. Exp Dermatol. 2016 07; 25(7):497-500. Hachey SJ, Boiko AD. PMID: 27060971.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    6. Profiling Melanoma Heterogeneity Using Microwell RNA Cytometry. Methods Mol Biol. 2016 Apr 16. Dimov IK, Boiko AD. PMID: 27083169.
      View in: PubMed   Mentions:    Fields:    
    7. Isolation of melanoma tumor-initiating cells from surgical tissues. Methods Mol Biol. 2013; 961:253-9. Boiko AD. PMID: 23325649.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1931-6. Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ. PMID: 21233420.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    9. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature. 2010 Jul 01; 466(7302):133-7. Boiko AD, Razorenova OV, van de Rijn M, Swetter SM, Johnson DL, Ly DP, Butler PD, Yang GP, Joshua B, Kaplan MJ, Longaker MT, Weissman IL. PMID: 20596026.
      View in: PubMed   Mentions: 256     Fields:    Translation:HumansAnimalsCells
    10. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev. 2006 Jan 15; 20(2):236-52. Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR, Gudkov AV. PMID: 16418486.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    11. Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7112-7. Lu T, Burdelya LG, Swiatkowski SM, Boiko AD, Howe PH, Stark GR, Gudkov AV. PMID: 15118089.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    12. Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes Dev. 2002 Nov 15; 16(22):2923-34. Zou X, Ray D, Aziyu A, Christov K, Boiko AD, Gudkov AV, Kiyokawa H. PMID: 12435633.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    13. Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response. Cancer Res. 1998 Aug 01; 58(15):3423-8. Axenovich SA, Kazarov AR, Boiko AD, Armin G, Roninson IB, Gudkov AV. PMID: 9699675.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
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